TRP-ing Down the Path to Insulin Secretion

Por MacDonald, Patrick E.
Publicado em 2011

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

Por MacDonald, Patrick E, Rorsman, Patrik
Publicado em 2006

cAMP-independent effects of GLP-1 on β cells

Por Kolic, Jelena, MacDonald, Patrick E.
Publicado no J Clin Invest (2015)

Glucose-sensing mechanisms in pancreatic β-cells

Por MacDonald, Patrick E, Joseph, Jamie W, Rorsman, Patrik
Publicado em 2005

Glucagon secretion and signaling in the development of diabetes

Por Gaisano, Herbert Y., MacDonald, Patrick E., Vranic, Mladen
Publicado em 2012

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

Por Vergari, Elisa, Plummer, Gregory, Dai, Xiaoqing, MacDonald, Patrick E.
Publicado em 2012

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic β-cells

Por MacDonald, Patrick E, Salapatek, Anne Marie F, Wheeler, Michael B
Publicado em 2003

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells

Por Braun, Matthias, Wendt, Anna, Karanauskaite, Jovita, Galvanovskis, Juris, Clark, Anne, MacDonald, Patrick E., Rorsman, Patrik
Publicado em 2007

Insulin Secretion Induced by Glucose-dependent Insulinotropic Polypeptide Requires Phosphatidylinositol 3-Kinase γ in Rodent and Human β-Cells

Por Kolic, Jelena, Spigelman, Aliya F., Smith, Alannah M., Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado no J Biol Chem (2014)

Intraislet SLIT–ROBO signaling is required for beta-cell survival and potentiates insulin secretion

Por Yang, Yu Hsuan Carol, Manning Fox, Jocelyn E., Zhang, Kevin L., MacDonald, Patrick E., Johnson, James D.
Publicado em 2013

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells

Por Dai, Xiao-Qing, Spigelman, Aliya F, Khan, Shara, Braun, Matthias, Manning Fox, Jocelyn E, MacDonald, Patrick E
Publicado em 2014

Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion

Por Patterson, Jessica N., Cousteils, Katelyn, Lou, Jennifer W., Manning Fox, Jocelyn E., MacDonald, Patrick E., Joseph, Jamie W.
Publicado em 2014

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets

Por Hajmrle, Catherine, Ferdaoussi, Mourad, Plummer, Gregory, Spigelman, Aliya F., Lai, Krista, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado em 2014

Interleukin-1 signaling contributes to acute islet compensation

Por Hajmrle, Catherine, Smith, Nancy, Spigelman, Aliya F., Dai, Xiaoqing, Senior, Laura, Bautista, Austin, Ferdaoussi, Mourad, MacDonald, Patrick E.
Publicado no JCI Insight (2016)

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

Por Ferdaoussi, Mourad, Fu, Jianyang, Dai, Xiaoqing, Manning Fox, Jocelyn E., Suzuki, Kunimasa, Smith, Nancy, Plummer, Gregory, MacDonald, Patrick E.
Publicado no Sci Rep (2017)

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Por Dai, Xiao-Qing, Plummer, Greg, Casimir, Marina, Kang, Youhou, Hajmrle, Catherine, Gaisano, Herbert Y., Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado em 2011

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

Por Kailey, Balrik, van de Bunt, Martijn, Cheley, Stephen, Johnson, Paul R., MacDonald, Patrick E., Gloyn, Anna L., Rorsman, Patrik, Braun, Matthias
Publicado em 2012

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Por Kolic, Jelena, Manning Fox, Jocelyn E., Chepurny, Oleg G., Spigelman, Aliya F., Ferdaoussi, Mourad, Schwede, Frank, Holz, George G., MacDonald, Patrick E.
Publicado no Mol Metab (2016)

A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

Por MacDonald, Patrick E, Marinis, Yang Zhang De, Ramracheya, Reshma, Salehi, Albert, Ma, Xiaosong, Johnson, Paul R. V, Cox, Roger, Eliasson, Lena, Rorsman, Patrik
Publicado em 2007

Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism

Por Gooding, Jessica R., Jensen, Mette V., Dai, Xiaoqing, Wenner, Brett R., Lu, Danhong, Arumugam, Ramamani, Ferdaoussi, Mourad, MacDonald, Patrick E., Newgard, Christopher B.
Publicado no Cell Rep (2015)