Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation?

Por Brandhorst, Daniel, Brandhorst, Heide, Johnson, Paul R.V.
Publicado no Rev Diabet Stud (2017)

Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity

Por Brandhorst, Heide, Johnson, Paul R. V., Korsgren, Olle, Brandhorst, Daniel
Publicado no Cell Transplant (2018)

Challenges of Improving the Evidence Base in Smaller Surgical Specialties, as Highlighted by a Systematic Review of Gastroschisis Management

Por Allin, Benjamin S. R., Tse, Win Hou W., Marven, Sean, Johnson, Paul R. V., Knight, Marian
Publicado no PLoS One (2015)

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

Por Beer, Nicola L., Tribble, Nicholas D., McCulloch, Laura J., Roos, Charlotta, Johnson, Paul R.V., Orho-Melander, Marju, Gloyn, Anna L.
Publicado em 2009

Development of a Simple In Vitro Assay to Assess Digestion of the Extracellular Matrix of the Human Pancreas by Collagenase Enzyme Blends

Por Spiers, Rebecca M., Cross, Sarah E., Brown, Helen L., Bateman, Paul A., Vaughan, Rebecca H., Hughes, Stephen J., Johnson, Paul R. V.
Publicado no Cell Transplant (2018)

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

Por Tarasov, Andrei I., Galvanovskis, Juris, Rorsman, Olof, Hamilton, Alexander, Vergari, Elisa, Johnson, Paul R. V., Reimann, Frank, Ashcroft, Frances M., Rorsman, Patrik
Publicado no Lab Chip (2018)

A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

Por MacDonald, Patrick E, Marinis, Yang Zhang De, Ramracheya, Reshma, Salehi, Albert, Ma, Xiaosong, Johnson, Paul R. V, Cox, Roger, Eliasson, Lena, Rorsman, Patrik
Publicado em 2007

Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation

Por Brandhorst, Daniel, Parnaud, Géraldine, Friberg, Andrew, Lavallard, Vanessa, Demuylder-Mischler, Sandrine, Hughes, Stephen, Saphörster, Julia, Kurfürst, Manfred, Korsgren, Olle, Berney, Thierry, Johnson, Paul R. V.
Publicado no Cell Transplant (2017)

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn(2+)

Por Chabosseau, Pauline, Tuncay, Erkan, Meur, Gargi, Bellomo, Elisa A., Hessels, Anne, Hughes, Stephen, Johnson, Paul R.V., Bugliani, Marco, Marchetti, Piero, Turan, Belma, Lyon, Alexander R., Merkx, Maarten, Rutter, Guy A.
Publicado no ACS Chem Biol (2014)

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

Por Gerber, Philipp A., Bellomo, Elisa A., Hodson, David J., Meur, Gargi, Solomou, Antonia, Mitchell, Ryan K., Hollinshead, Michael, Chimienti, Fabrice, Bosco, Domenico, Hughes, Stephen J., Johnson, Paul R. V., Rutter, Guy A.
Publicado em 2014

Improved Baculovirus Vectors for Transduction and Gene Expression in Human Pancreatic Islet Cells

Por Graves, Leo P., Aksular, Mine, Alakeely, Riyadh A., Ruiz Buck, Daniel, Chambers, Adam C., Murguia-Meca, Fernanda, Plata-Muñoz, Juan-Jose, Hughes, Stephen, Johnson, Paul R. V., Possee, Robert D., King, Linda A.
Publicado no Viruses (2018)

Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program fo...

Por Aldibbiat, Ali, Huang, Guo Cai, Zhao, Min, Holliman, Graham N., Ferguson, Linda, Hughes, Stephen, Brigham, Ken, Wardle, Julie, Williams, Rob, Dickinson, Anne, White, Steven A., Johnson, Paul R. V., Manas, Derek, Amiel, Stephanie A., Shaw, James A. M.
Publicado no Cell Med (2011)

Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca(2+) mobilization from acidic stores in pancreatic α-cells

Por Hamilton, Alexander, Zhang, Quan, Salehi, Albert, Willems, Mara, Knudsen, Jakob G., Stephen, Sam, Ringgaard, Anna K., Chapman, Caroline E., Gonzalez-Alvarez, Alejandro, Surdo, Nicoletta C., Zaccolo, Manuela, Basco, Davide, Johnson, Paul R.V., Ramracheya, Reshma, Rutter, Guy A., Galione, Antony, Rorsman, Patrik, Tarasov, Andrei I.
Publicado no Diabetes (2018)

Role of K(ATP) Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Por Zhang, Quan, Ramracheya, Reshma, Lahmann, Carolina, Tarasov, Andrei, Bengtsson, Martin, Braha, Orit, Braun, Matthias, Brereton, Melissa, Collins, Stephan, Galvanovskis, Juris, Gonzalez, Alejandro, Groschner, Lukas N., Rorsman, Nils J.G., Salehi, Albert, Travers, Mary E., Walker, Jonathan N., Gloyn, Anna L., Gribble, Fiona, Johnson, Paul R.V., Reimann, Frank, Ashcroft, Frances M., Rorsman, Patrik
Publicado em 2013

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Por Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I., Cha, Chae Young, Chibalina, Margarita V., Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R., Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O., Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R.V., Kaku, Kohei, Ladds, Graham, Rorsman, Patrik
Publicado no J Clin Invest (2015)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes

Por Rosengren, Anders H., Braun, Matthias, Mahdi, Taman, Andersson, Sofia A., Travers, Mary E., Shigeto, Makoto, Zhang, Enming, Almgren, Peter, Ladenvall, Claes, Axelsson, Annika S., Edlund, Anna, Pedersen, Morten Gram, Jonsson, Anna, Ramracheya, Reshma, Tang, Yunzhao, Walker, Jonathan N., Barrett, Amy, Johnson, Paul R.V., Lyssenko, Valeriya, McCarthy, Mark I., Groop, Leif, Salehi, Albert, Gloyn, Anna L., Renström, Erik, Rorsman, Patrik, Eliasson, Lena
Publicado em 2012

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants

Por Nicolson, Tamara J., Bellomo, Elisa A., Wijesekara, Nadeeja, Loder, Merewyn K., Baldwin, Jocelyn M., Gyulkhandanyan, Armen V., Koshkin, Vasilij, Tarasov, Andrei I., Carzaniga, Raffaella, Kronenberger, Katrin, Taneja, Tarvinder K., da Silva Xavier, Gabriela, Libert, Sarah, Froguel, Philippe, Scharfmann, Raphael, Stetsyuk, Volodymir, Ravassard, Philippe, Parker, Helen, Gribble, Fiona M., Reimann, Frank, Sladek, Robert, Hughes, Stephen J., Johnson, Paul R.V., Masseboeuf, Myriam, Burcelin, Remy, Baldwin, Stephen A., Liu, Ming, Lara-Lemus, Roberto, Arvan, Peter, Schuit, Frans C., Wheeler, Michael B., Chimienti, Fabrice, Rutter, Guy A.
Publicado em 2009

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Por Voight, Benjamin F, Scott, Laura J, Steinthorsdottir, Valgerdur, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, Thorleifsson, Gudmar, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J, Raychaudhuri, Soumya, McCarroll, Steve A, Langenberg, Claudia, Hofmann, Oliver M, Dupuis, Josée, Qi, Lu, Segrè, Ayellet V, van Hoek, Mandy, Navarro, Pau, Ardlie, Kristin, Balkau, Beverley, Benediktsson, Rafn, Bennett, Amanda J, Blagieva, Roza, Boerwinkle, Eric, Bonnycastle, Lori L, Boström, Kristina Bengtsson, Bravenboer, Bert, Bumpstead, Suzannah, Burtt, Noisël P, Charpentier, Guillaume, Chines, Peter S, Cornelis, Marilyn, Couper, David J, Crawford, Gabe, Doney, Alex S F, Elliott, Katherine S, Elliott, Amanda L, Erdos, Michael R, Fox, Caroline S, Franklin, Christopher S, Ganser, Martha, Gieger, Christian, Grarup, Niels, Green, Todd, Griffin, Simon, Groves, Christopher J, Guiducci, Candace, Hadjadj, Samy, Hassanali, Neelam, Herder, Christian, Isomaa, Bo, Jackson, Anne U, Johnson, Paul R V, Jørgensen, Torben, Kao, Wen H L, Klopp, Norman, Kong, Augustine, Kraft, Peter, Kuusisto, Johanna, Lauritzen, Torsten, Li, Man, Lieverse, Aloysius, Lindgren, Cecilia M, Lyssenko, Valeriya, Marre, Michel, Meitinger, Thomas, Midthjell, Kristian, Morken, Mario A, Narisu, Narisu, Nilsson, Peter, Owen, Katharine R, Payne, Felicity, Perry, John R B, Petersen, Ann-Kristin, Platou, Carl, Proença, Christine, Prokopenko, Inga, Rathmann, Wolfgang, Rayner, N William, Robertson, Neil R, Rocheleau, Ghislain, Roden, Michael, Sampson, Michael J, Saxena, Richa, Shields, Beverley M, Shrader, Peter, Sigurdsson, Gunnar, Sparsø, Thomas, Strassburger, Klaus, Stringham, Heather M, Sun, Qi, Swift, Amy J, Thorand, Barbara, Tichet, Jean, Tuomi, Tiinamaija, van Dam, Rob M, van Haeften, Timon W, van Herpt, Thijs, van Vliet-Ostaptchouk, Jana V, Walters, G Bragi, Weedon, Michael N, Wijmenga, Cisca, Witteman, Jacqueline, Bergman, Richard N, Cauchi, Stephane, Collins, Francis S, Gloyn, Anna L, Gyllensten, Ulf, Hansen, Torben, Hide, Winston A, Hitman, Graham A, Hofman, Albert, Hunter, David J, Hveem, Kristian, Laakso, Markku, Mohlke, Karen L, Morris, Andrew D, Palmer, Colin N A, Pramstaller, Peter P, Rudan, Igor, Sijbrands, Eric, Stein, Lincoln D, Tuomilehto, Jaakko, Uitterlinden, Andre, Walker, Mark, Wareham, Nicholas J, Watanabe, Richard M, Abecasis, Gonçalo R, Boehm, Bernhard O, Campbell, Harry, Daly, Mark J, Hattersley, Andrew T, Hu, Frank B, Meigs, James B, Pankow, James S, Pedersen, Oluf, Wichmann, H-Erich, Barroso, Inês, Florez, Jose C, Frayling, Timothy M, Groop, Leif, Sladek, Rob, Thorsteinsdottir, Unnur, Wilson, James F, Illig, Thomas, Froguel, Philippe, van Duijn, Cornelia M, Stefansson, Kari, Altshuler, David, Boehnke, Michael, McCarthy, Mark I
Publicado em 2010

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Por Dupuis, Josée, Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Soranzo, Nicole, Jackson, Anne U, Wheeler, Eleanor, Glazer, Nicole L, Bouatia-Naji, Nabila, Gloyn, Anna L, Lindgren, Cecilia M, Mägi, Reedik, Morris, Andrew P, Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, Henneman, Peter, Grallert, Harald, Dehghan, Abbas, Hottenga, Jouke Jan, Franklin, Christopher S, Navarro, Pau, Song, Kijoung, Goel, Anuj, Perry, John R B, Egan, Josephine M, Lajunen, Taina, Grarup, Niels, Sparsø, Thomas, Doney, Alex, Voight, Benjamin F, Stringham, Heather M, Li, Man, Kanoni, Stavroula, Shrader, Peter, Cavalcanti-Proença, Christine, Kumari, Meena, Qi, Lu, Timpson, Nicholas J, Gieger, Christian, Zabena, Carina, Rocheleau, Ghislain, Ingelsson, Erik, An, Ping, O’Connell, Jeffrey, Luan, Jian'an, Elliott, Amanda, McCarroll, Steven A, Payne, Felicity, Roccasecca, Rosa Maria, Pattou, François, Sethupathy, Praveen, Ardlie, Kristin, Ariyurek, Yavuz, Balkau, Beverley, Barter, Philip, Beilby, John P, Ben-Shlomo, Yoav, Benediktsson, Rafn, Bennett, Amanda J, Bergmann, Sven, Bochud, Murielle, Boerwinkle, Eric, Bonnefond, Amélie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Bumpstead, Suzannah J, Charpentier, Guillaume, Chen, Yii-Der Ida, Chines, Peter, Clarke, Robert, Coin, Lachlan J M, Cooper, Matthew N, Cornelis, Marilyn, Crawford, Gabe, Crisponi, Laura, Day, Ian N M, de Geus, Eco, Delplanque, Jerome, Dina, Christian, Erdos, Michael R, Fedson, Annette C, Fischer-Rosinsky, Antje, Forouhi, Nita G, Fox, Caroline S, Frants, Rune, Franzosi, Maria Grazia, Galan, Pilar, Goodarzi, Mark O, Graessler, Jürgen, Groves, Christopher J, Grundy, Scott, Gwilliam, Rhian, Gyllensten, Ulf, Hadjadj, Samy, Hallmans, Göran, Hammond, Naomi, Han, Xijing, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hayward, Caroline, Heath, Simon C, Hercberg, Serge, Herder, Christian, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hofman, Albert, Hui, Jennie, Hung, Joe, Isomaa, Bo, Johnson, Paul R V, Jørgensen, Torben, Jula, Antti, Kaakinen, Marika, Kaprio, Jaakko, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Koskinen, Seppo, Kovacs, Peter, Kyvik, Kirsten Ohm, Lathrop, G Mark, Lawlor, Debbie A, Le Bacquer, Olivier, Lecoeur, Cécile, Li, Yun, Lyssenko, Valeriya, Mahley, Robert, Mangino, Massimo, Manning, Alisa K, Martínez-Larrad, María Teresa, McAteer, Jarred B, McCulloch, Laura J, McPherson, Ruth, Meisinger, Christa, Melzer, David, Meyre, David, Mitchell, Braxton D, Morken, Mario A, Mukherjee, Sutapa, Naitza, Silvia, Narisu, Narisu, Neville, Matthew J, Oostra, Ben A, Orrù, Marco, Pakyz, Ruth, Palmer, Colin N A, Paolisso, Giuseppe, Pattaro, Cristian, Pearson, Daniel, Peden, John F, Pedersen, Nancy L., Perola, Markus, Pfeiffer, Andreas F H, Pichler, Irene, Polasek, Ozren, Posthuma, Danielle, Potter, Simon C, Pouta, Anneli, Province, Michael A, Psaty, Bruce M, Rathmann, Wolfgang, Rayner, Nigel W, Rice, Kenneth, Ripatti, Samuli, Rivadeneira, Fernando, Roden, Michael, Rolandsson, Olov, Sandbaek, Annelli, Sandhu, Manjinder, Sanna, Serena, Sayer, Avan Aihie, Scheet, Paul, Scott, Laura J, Seedorf, Udo, Sharp, Stephen J, Shields, Beverley, Sigurðsson, Gunnar, Sijbrands, Erik J G, Silveira, Angela, Simpson, Laila, Singleton, Andrew, Smith, Nicholas L, Sovio, Ulla, Swift, Amy, Syddall, Holly, Syvänen, Ann-Christine, Tanaka, Toshiko, Thorand, Barbara, Tichet, Jean, Tönjes, Anke, Tuomi, Tiinamaija, Uitterlinden, André G, van Dijk, Ko Willems, van Hoek, Mandy, Varma, Dhiraj, Visvikis-Siest, Sophie, Vitart, Veronique, Vogelzangs, Nicole, Waeber, Gérard, Wagner, Peter J, Walley, Andrew, Walters, G Bragi, Ward, Kim L, Watkins, Hugh, Weedon, Michael N, Wild, Sarah H, Willemsen, Gonneke, Witteman, Jaqueline C M, Yarnell, John W G, Zeggini, Eleftheria, Zelenika, Diana, Zethelius, Björn, Zhai, Guangju, Zhao, Jing Hua, Zillikens, M Carola, Borecki, Ingrid B, Loos, Ruth J F, Meneton, Pierre, Magnusson, Patrik K E, Nathan, David M, Williams, Gordon H, Hattersley, Andrew T, Silander, Kaisa, Salomaa, Veikko, Smith, George Davey, Bornstein, Stefan R, Schwarz, Peter, Spranger, Joachim, Karpe, Fredrik, Shuldiner, Alan R, Cooper, Cyrus, Dedoussis, George V, Serrano-Ríos, Manuel, Morris, Andrew D, Lind, Lars, Palmer, Lyle J, Hu, Frank B., Franks, Paul W, Ebrahim, Shah, Marmot, Michael, Kao, W H Linda, Pankow, James S, Sampson, Michael J, Kuusisto, Johanna, Laakso, Markku, Hansen, Torben, Pedersen, Oluf, Pramstaller, Peter Paul, Wichmann, H Erich, Illig, Thomas, Rudan, Igor, Wright, Alan F, Stumvoll, Michael, Campbell, Harry, Wilson, James F, Hamsten, Anders, Bergman, Richard N, Buchanan, Thomas A, Collins, Francis S, Mohlke, Karen L, Tuomilehto, Jaakko, Valle, Timo T, Altshuler, David, Rotter, Jerome I, Siscovick, David S, Penninx, Brenda W J H, Boomsma, Dorret, Deloukas, Panos, Spector, Timothy D, Frayling, Timothy M, Ferrucci, Luigi, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, van Duijn, Cornelia M, Aulchenko, Yurii S, Cao, Antonio, Scuteri, Angelo, Schlessinger, David, Uda, Manuela, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Waterworth, Dawn M, Vollenweider, Peter, Peltonen, Leena, Mooser, Vincent, Abecasis, Goncalo R, Wareham, Nicholas J, Sladek, Robert, Froguel, Philippe, Watanabe, Richard M, Meigs, James B, Groop, Leif, Boehnke, Michael, McCarthy, Mark I, Florez, Jose C, Barroso, Inês
Publicado em 2010