Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca(2+) mobilization from acidic stores in pancreatic α-cells

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors but the downstream mechanisms have only been partially elucidated. Here we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca(...

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Publicado en:Diabetes
Autores principales: Hamilton, Alexander, Zhang, Quan, Salehi, Albert, Willems, Mara, Knudsen, Jakob G., Stephen, Sam, Ringgaard, Anna K., Chapman, Caroline E., Gonzalez-Alvarez, Alejandro, Surdo, Nicoletta C., Zaccolo, Manuela, Basco, Davide, Johnson, Paul R.V., Ramracheya, Reshma, Rutter, Guy A., Galione, Antony, Rorsman, Patrik, Tarasov, Andrei I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258900/
https://ncbi.nlm.nih.gov/pubmed/29563152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1102
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