α-cell glucokinase suppresses glucose-regulated glucagon secretion

Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 and type 2 diabetes. Here, we show that α-cell glucokinase (Gck) plays a role in the control of glucagon secretion. Usi...

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Publicado en:Nat Commun
Main Authors: Basco, Davide, Zhang, Quan, Salehi, Albert, Tarasov, Andrei, Dolci, Wanda, Herrera, Pedro, Spiliotis, Ioannis, Berney, Xavier, Tarussio, David, Rorsman, Patrik, Thorens, Bernard
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803227/
https://ncbi.nlm.nih.gov/pubmed/29416045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03034-0
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