GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. Here, we examined the mech...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I., Cha, Chae Young, Chibalina, Margarita V., Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R., Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O., Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R.V., Kaku, Kohei, Ladds, Graham, Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665783/
https://ncbi.nlm.nih.gov/pubmed/26571400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81975
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