GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. Here, we examined the mech...

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書誌詳細
出版年:J Clin Invest
主要な著者: Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I., Cha, Chae Young, Chibalina, Margarita V., Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R., Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O., Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R.V., Kaku, Kohei, Ladds, Graham, Rorsman, Patrik
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665783/
https://ncbi.nlm.nih.gov/pubmed/26571400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81975
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