GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. Here, we examined the mech...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I., Cha, Chae Young, Chibalina, Margarita V., Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R., Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O., Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R.V., Kaku, Kohei, Ladds, Graham, Rorsman, Patrik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665783/
https://ncbi.nlm.nih.gov/pubmed/26571400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81975
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