Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

AIMS/HYPOTHESIS: Hypoxic damage complicates islet isolation for transplantation and may contribute to beta cell failure in type 2 diabetes. Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic...

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Autores principales: Gerber, Philipp A., Bellomo, Elisa A., Hodson, David J., Meur, Gargi, Solomou, Antonia, Mitchell, Ryan K., Hollinshead, Michael, Chimienti, Fabrice, Bosco, Domenico, Hughes, Stephen J., Johnson, Paul R. V., Rutter, Guy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079946/
https://ncbi.nlm.nih.gov/pubmed/24865615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3266-0
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