Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules. Although a common nonsynonymous polymorphism (R325W), which lowers activity, is associated with increased type 2 diabetes (T2D) risk, rar...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Endocrinol
Auteurs principaux: Mitchell, Ryan K., Hu, Ming, Chabosseau, Pauline L., Cane, Matthew C., Meur, Gargi, Bellomo, Elisa A., Carzaniga, Raffaella, Collinson, Lucy M., Li, Wen-Hong, Hodson, David J., Rutter, Guy A.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2016
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995240/
https://ncbi.nlm.nih.gov/pubmed/26584158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1227
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