The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic islet β- and α-cells, and responsible for zinc accumulation into secretory granules. Although common SLC30A8 variants, believed to reduce ZnT8 activity, increase type 2 diabetes risk in humans, rare inactivating mutations are p...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Solomou, Antonia, Meur, Gargi, Bellomo, Elisa, Hodson, David J., Tomas, Alejandra, Migrenne Li, Stéphanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, Rutter, Guy A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571871/
https://ncbi.nlm.nih.gov/pubmed/26178371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645291
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars