Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia

BACKGROUND: The human SLC30A8 gene encodes the secretory granule-localised zinc transporter ZnT8 whose expression is chiefly restricted to the endocrine pancreas. Single nucleotide polymorphisms (SNPs) in the human SLC30A8 gene have been associated, through genome-wide studies, with altered type 2 d...

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Publicat a:Nutr Metab (Lond)
Autors principals: Solomou, Antonia, Philippe, Erwann, Chabosseau, Pauline, Migrenne-Li, Stephanie, Gaitan, Julien, Lang, Jochen, Magnan, Christophe, Rutter, Guy A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936320/
https://ncbi.nlm.nih.gov/pubmed/27390586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-016-0104-z
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