A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed to neuronal control, paracrine control by neighbouring β cells, or to an intrinsic glucose sensing by the α cells...

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Detalhes bibliográficos
Main Authors: MacDonald, Patrick E, Marinis, Yang Zhang De, Ramracheya, Reshma, Salehi, Albert, Ma, Xiaosong, Johnson, Paul R. V, Cox, Roger, Eliasson, Lena, Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868042/
https://ncbi.nlm.nih.gov/pubmed/17503968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050143
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