Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

OBJECTIVE: To document the properties of the voltage-gated ion channels in human pancreatic α-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS: Glucagon release was measured from intact islets. [Ca(2+)](i) was recorded in cells showing spontaneous activity at 1 mmol/l glucose. M...

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Detalhes bibliográficos
Main Authors: Ramracheya, Reshma, Ward, Caroline, Shigeto, Makoto, Walker, Jonathan N., Amisten, Stefan, Zhang, Quan, Johnson, Paul R., Rorsman, Patrik, Braun, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927942/
https://ncbi.nlm.nih.gov/pubmed/20547976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1505
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