γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells

OBJECTIVE: Paracrine signaling via γ-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets. RESEARCH DESIGN AND METHODS: Expression of GABA(A)Rs in islet cells was investi...

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Detalhes bibliográficos
Main Authors: Braun, Matthias, Ramracheya, Reshma, Bengtsson, Martin, Clark, Anne, Walker, Jonathan N., Johnson, Paul R., Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889769/
https://ncbi.nlm.nih.gov/pubmed/20413510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0797
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