GLP‐1 suppresses glucagon secretion in human pancreatic alpha‐cells by inhibition of P/Q‐type Ca(2+) channels

Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it both stimulates insulin and inhibits glucagon secretio...

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Bibliografiske detaljer
Udgivet i:Physiol Rep
Main Authors: Ramracheya, Reshma, Chapman, Caroline, Chibalina, Margarita, Dou, Haiqiang, Miranda, Caroline, González, Alejandro, Moritoh, Yusuke, Shigeto, Makoto, Zhang, Quan, Braun, Matthias, Clark, Anne, Johnson, Paul R., Rorsman, Patrik, Briant, Linford J. B.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125244/
https://ncbi.nlm.nih.gov/pubmed/30187652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13852
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