SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1–5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR activation r...

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Autores principales: Kailey, Balrik, van de Bunt, Martijn, Cheley, Stephen, Johnson, Paul R., MacDonald, Patrick E., Gloyn, Anna L., Rorsman, Patrik, Braun, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492856/
https://ncbi.nlm.nih.gov/pubmed/22932785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00207.2012
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