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SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1–5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR activation r...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492856/ https://ncbi.nlm.nih.gov/pubmed/22932785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00207.2012 |
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