SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets

Posttranslational modification by the small ubiquitin-like modifier (SUMO) peptides, known as SUMOylation, is reversed by the sentrin/SUMO-specific proteases (SENPs). While increased SUMOylation reduces β-cell exocytosis, insulin secretion, and responsiveness to GLP-1, the impact of SUMOylation on i...

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Bibliographische Detailangaben
Hauptverfasser: Hajmrle, Catherine, Ferdaoussi, Mourad, Plummer, Gregory, Spigelman, Aliya F., Lai, Krista, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200309/
https://ncbi.nlm.nih.gov/pubmed/25139051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00168.2014
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