Interleukin-1 signaling contributes to acute islet compensation

IL-1β is a well-established inducer of both insulin resistance and impaired pancreatic islet function. Despite this, findings examining IL-1 receptor deficiency or antagonism in in vivo animal models, as well as in clinical studies of type 2 diabetic (T2D) patients, have led to conflicting results,...

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Pubblicato in:JCI Insight
Autori principali: Hajmrle, Catherine, Smith, Nancy, Spigelman, Aliya F., Dai, Xiaoqing, Senior, Laura, Bautista, Austin, Ferdaoussi, Mourad, MacDonald, Patrick E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033842/
https://ncbi.nlm.nih.gov/pubmed/27699257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86055
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