PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

OBJECTIVES: Phosphatidylinositol-3-OH kinase (PI3K) signalling in the endocrine pancreas contributes to glycaemic control. However, the mechanism by which PI3K modulates insulin secretion from the pancreatic beta cell is poorly understood. Thus, our objective was two-fold; to determine the signallin...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Kolic, Jelena, Manning Fox, Jocelyn E., Chepurny, Oleg G., Spigelman, Aliya F., Ferdaoussi, Mourad, Schwede, Frank, Holz, George G., MacDonald, Patrick E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921792/
https://ncbi.nlm.nih.gov/pubmed/27408772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.05.003
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