Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

cAMP-elevating agents such as the incretin hormone glucagon-like peptide-1 potentiate glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. However, a debate has existed since the 1970s concerning whether or not cAMP signaling is essential for glucose alone to stimulate insulin secret...

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Foilsithe in:Mol Endocrinol
Main Authors: Schwede, Frank, Chepurny, Oleg G., Kaufholz, Melanie, Bertinetti, Daniela, Leech, Colin A., Cabrera, Over, Zhu, Yingmin, Mei, Fang, Cheng, Xiaodong, Manning Fox, Jocelyn E., MacDonald, Patrick E., Genieser, Hans-G., Herberg, Friedrich W., Holz, George G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Endocrine Society 2015
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484784/
https://ncbi.nlm.nih.gov/pubmed/26061564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1330
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