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“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

The activity of the archetypal protein kinase A (PKA) is typically thought of in regards to the catalytic subunit, which is inhibited by the regulatory subunits in the absence of cAMP. However, it is now reported that one of the regulatory subunit isoforms (PKA-RIα) takes on a function of its own up...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Holz, George G., Chepurny, Oleg G., Leech, Colin A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378975/
https://ncbi.nlm.nih.gov/pubmed/30765510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H119.007622
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