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“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

The activity of the archetypal protein kinase A (PKA) is typically thought of in regards to the catalytic subunit, which is inhibited by the regulatory subunits in the absence of cAMP. However, it is now reported that one of the regulatory subunit isoforms (PKA-RIα) takes on a function of its own up...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Holz, George G., Chepurny, Oleg G., Leech, Colin A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378975/
https://ncbi.nlm.nih.gov/pubmed/30765510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H119.007622
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