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Expression of cAMP-Regulated Guanine Nucleotide Exchange Factors in Pancreatic β-Cells

The insulinotropic hormone glucagon-like peptide-1 (GLP-1) binds to a Gs-coupled receptor on pancreatic β-cells and potentiates glucose-induced insulin secretion, insulin gene transcription, and β-cell growth. These stimulatory effects have been attributed to the elevation of intracellular cAMP leve...

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Detalhes bibliográficos
Main Authors: Leech, Colin A., Holz, George G., Chepurny, Oleg, Habener, Joel F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924611/
https://ncbi.nlm.nih.gov/pubmed/11071853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/bbrc.2000.3763
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