Diabetes Outfoxed by GLP-1?

Por Holz, George G., Chepurny, Oleg G.
Publicado em 2005

Glucagon-Like Peptide-1 Synthetic Analogs: New Therapeutic Agents for Use in the Treatment of Diabetes Mellitus

Por Holz, George G., Chepurny, Oleg G.
Publicado em 2003

A Novel Cyclic Adenosine Monophosphate–Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance fo...

Por CHEPURNY, OLEG G., HOLZ, GEORGE G.
Publicado em 2007

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic β-ce...

Por Chepurny, Oleg G., Holz, George G.
Publicado em 2002

Epac-Selective cAMP Analogs: New Tools With Which To Evaluate The Signal Transduction Properties Of cAMP-Regulated Guanine Nucleotide Exchange Factors

Por Holz, George G., Chepurny, Oleg G., Schwede, Frank
Publicado em 2007

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca(2+)-induced Ca(2+) release in INS-1 pancreatic β-cells

Por Kang, Guoxin, Chepurny, Oleg G, Holz, George G
Publicado em 2001

Regulation of Glucose Homeostasis by GLP-1

Por Nadkarni, Prashant, Chepurny, Oleg G., Holz, George G.
Publicado em 2014

Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Por Leech, Colin A., Chepurny, Oleg G., Holz, George G.
Publicado em 2010

Exendin-4 as a Stimulator of Rat Insulin I Gene Promoter Activity via bZIP/CRE Interactions Sensitive to Serine/Threonine Protein Kinase Inhibitor Ro 31-8220

Por CHEPURNY, OLEG G., HUSSAIN, MEHBOOB A., HOLZ, GEORGE G.
Publicado em 2002

Epac2A Makes a New Impact in β-Cell Biology

Por Holz, George G., Chepurny, Oleg G., Leech, Colin A.
Publicado em 2013

Leptin-stimulated K(ATP) channel trafficking: A new paradigm for β-cell stimulus-secretion coupling?

Por Holz, George G, Chepurny, Oleg G, Leech, Colin A
Publicado em 2013

New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice

Por Holz, George G., Leech, Colin A., Chepurny, Oleg G.
Publicado no Biochim Biophys Acta (2014)

“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

Por Holz, George G., Chepurny, Oleg G., Leech, Colin A.
Publicado no J Biol Chem (2019)

Expression of cAMP-Regulated Guanine Nucleotide Exchange Factors in Pancreatic β-Cells

Por Leech, Colin A., Holz, George G., Chepurny, Oleg, Habener, Joel F.
Publicado em 2000

FRET Reporter Assays for cAMP and Calcium in a 96-well Format Using Genetically Encoded Biosensors Expressed in Living Cells

Por Milliken, Brandon T., Doyle, Robert P., Holz, George G., Chepurny, Oleg G.
Publicado no Bio Protoc (2020)

GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion

Por Chepurny, Oleg G., Holz, George G., Roe, Michael W., Leech, Colin A.
Publicado no Mol Endocrinol (2016)

Cell physiology of cAMP sensor Epac

Por Holz, George G, Kang, Guoxin, Harbeck, Mark, Roe, Michael W, Chepurny, Oleg G
Publicado em 2006

Role of the cAMP sensor Epac as a determinant of K(ATP) channel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells

Por Kang, Guoxin, Leech, Colin A, Chepurny, Oleg G, Coetzee, William A, Holz, George G
Publicado em 2008

Synthesis, Characterization and Pharmacodynamics of Vitamin-B(12)-Conjugated Glucagon-Like Peptide-1

Por Clardy-James, Susan, Chepurny, Oleg G., Leech, Colin A., Holz, George G., Doyle, Robert P.
Publicado em 2012

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B(12) Conjugate of Exendin-4

Por Bonaccorso, Ron L., Chepurny, Oleg G., Becker-Pauly, Christoph, Holz, George G., Doyle, Robert P.
Publicado no Mol Pharm (2015)