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FRET Reporter Assays for cAMP and Calcium in a 96-well Format Using Genetically Encoded Biosensors Expressed in Living Cells

Stimulation of G protein-coupled receptors (GPCR) by hormones and neurotransmitters elicits cellular responses, many of which result from alterations in the concentrations of cytosolic cAMP and Ca(2+). Here, we describe a microplate reader fluorescence resonance energy transfer (FRET) assay that use...

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Detalhes bibliográficos
Publicado no:Bio Protoc
Main Authors: Milliken, Brandon T., Doyle, Robert P., Holz, George G., Chepurny, Oleg G.
Formato: Artigo
Idioma:Inglês
Publicado em: Bio-Protocol 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409823/
https://ncbi.nlm.nih.gov/pubmed/32775537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3641
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