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Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B(12) Conjugate of Exendin-4
Peptide digestion from proteases is a significant limitation in peptide therapeutic development. It has been hypothesized that the dietary pathway of vitamin B(12) (B(12)) may be exploited in this area, but an open question is whether B(12)-peptide conjugates bound to the B(12) gastric uptake protei...
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| Publicado no: | Mol Pharm |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660977/ https://ncbi.nlm.nih.gov/pubmed/26260673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00390 |
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