Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

[Image: see text] Corrination is the conjugation of a corrin ring containing molecule, such as vitamin B(12) (B12) or B12 biosynthetic precursor dicyanocobinamide (Cbi), to small molecules, peptides, or proteins with the goal of modifying pharmacology. Recently, a corrinated GLP-1R agonist (GLP-1RA)...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Tinsley, Ian C., Borner, Tito, Swanson, MacKenzie L., Chepurny, Oleg G., Doebley, Sarah A., Kamat, Varun, Sweet, Ian R., Holz, George G., Hayes, Matthew R., De Jonghe, Bart C., Doyle, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279408/
https://ncbi.nlm.nih.gov/pubmed/33677970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00185
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