Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R agonist c...

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Udgivet i:Cell Rep
Main Authors: Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376604/
https://ncbi.nlm.nih.gov/pubmed/32553160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107768
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