Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R agonist c...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376604/
https://ncbi.nlm.nih.gov/pubmed/32553160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107768
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