The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats

por Liberini, Claudia G., Borner, Tito, Boyle, Christina N., Lutz, Thomas A.
Publicado en Mol Metab (2016)

Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15

por Borner, Tito, Arnold, Myrtha, Ruud, Johan, Breit, Samuel N., Langhans, Wolfgang, Lutz, Thomas A., Blomqvist, Anders, Riediger, Thomas
Publicado en J Cachexia Sarcopenia Muscle (2016)

Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation

por Leon, Rosa M., Borner, Tito, Reiner, David J., Stein, Lauren M., Lhamo, Rinzin, De Jonghe, Bart C., Hayes, Matthew R.
Publicado en Neuropsychopharmacology (2019)

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

por Fortin, Samantha M., Lipsky, Rachele K., Lhamo, Rinzin, Chen, Jack, Kim, Eun, Borner, Tito, Schmidt, Heath D., Hayes, Matthew R.
Publicado en Sci Transl Med (2020)

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

por Borner, Tito, Wald, Hallie S., Ghidewon, Misgana Y., Zhang, Bei, Wu, Zhidan, De Jonghe, Bart C., Breen, Danna, Grill, Harvey J.
Publicado en Cell Rep (2020)

Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats

por Leon, Rosa M., Borner, Tito, Stein, Lauren M., Urrutia, Norma A., De Jonghe, Bart C., Schmidt, Heath D., Hayes, Matthew R.
Publicado en Neuropharmacology (2021)

A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models

por Borner, Tito, Shaulson, Evan D., Tinsley, Ian C., Stein, Lauren M., Horn, Charles C., Hayes, Matthew R., Doyle, Robert P., De Jonghe, Bart C.
Publicado en Diabetes Obes Metab (2020)

GDF15 Induces Anorexia through Nausea and Emesis

por Borner, Tito, Shaulson, Evan D., Ghidewon, Misgana Y., Barnett, Amanda B., Horn, Charles C., Doyle, Robert P., Grill, Harvey J., Hayes, Matthew R., De Jonghe, Bart C.
Publicado en Cell Metab (2020)

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

por Milliken, Brandon T., Elfers, Clinton, Chepurny, Oleg G., Chichura, Kylie S., Sweet, Ian R., Borner, Tito, Hayes, Matthew R., De Jonghe, Bart C., Holz, George G., Roth, Christian L., Doyle, Robert P.
Publicado en J Med Chem (2021)

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

por Tinsley, Ian C., Borner, Tito, Swanson, MacKenzie L., Chepurny, Oleg G., Doebley, Sarah A., Kamat, Varun, Sweet, Ian R., Holz, George G., Hayes, Matthew R., De Jonghe, Bart C., Doyle, Robert P.
Publicado en J Med Chem (2021)

A Vitamin B12 Conjugate of Exendin-4 Improves Glucose Tolerance Without Associated Nausea or Hypophagia in Rodents

por Mietlicki-Baase, Elizabeth G., Liberini, Claudia G., Workinger, Jayme L., Bonaccorso, Ron L., Borner, Tito, Reiner, David J., Koch-Laskowski, Kieran, McGrath, Lauren E., Lhamo, Rinzin, Stein, Lauren M., De Jonghe, Bart C., Holz, George G., Roth, Christian L., Doyle, Robert P., Hayes, Matthew R.
Publicado en Diabetes Obes Metab (2018)

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

por Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
Publicado en Cell Rep (2020)