A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models

AIM: To develop a conjugate of vitamin B12 bound to the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex4) that shows reduced penetrance into the central nervous system while maintaining peripheral glucoregulatory function. METHODS: We evaluated whether a vitamin B12 conjugate of Ex4...

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Detalhes bibliográficos
Publicado no:Diabetes Obes Metab
Main Authors: Borner, Tito, Shaulson, Evan D., Tinsley, Ian C., Stein, Lauren M., Horn, Charles C., Hayes, Matthew R., Doyle, Robert P., De Jonghe, Bart C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927944/
https://ncbi.nlm.nih.gov/pubmed/32410372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.14089
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