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Solution Structure and Constrained Molecular Dynamics Study of Vitamin B(12) Conjugates of the Anorectic Peptide PYY(3–36)

Vitamin B(12)–peptide conjugates have considerable therapeutic potential through improved pharmacokinetic and/or pharmacodynamic properties imparted on the peptide upon covalent attachment to vitamin B(12) (B(12)). There remains a lack of structural studies investigating the effects of B(12) conjuga...

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Bibliografske podrobnosti
izdano v:	ChemMedChem
Main Authors:	Henry, Kelly E., Kerwood, Deborah J., Allis, Damian G., Workinger, Jayme L., Bonaccorso, Ron L., Holz, George G., Roth, Christian L., Zubieta, Jon, Doyle, Robert P.
Format:	Artigo
Jezik:	Inglês
Izdano:	2016
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4878914/ https://ncbi.nlm.nih.gov/pubmed/27027248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600073
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Solution Structure and Constrained Molecular Dynamics Study of Vitamin B(12) Conjugates of the Anorectic Peptide PYY(3–36)

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