Vitamin B(12) Conjugation of Peptide-YY(3–36) Decreases Food Intake Compared to Native Peptide-YY(3–36) Upon Subcutaneous Administration in Male Rats

Challenges to peptide-based therapies include rapid clearance, ready degradation by hydrolysis/proteolysis, and poor intestinal uptake and/or a need for blood brain barrier transport. This work evaluates the efficacy of conjugation of vitamin B(12) (B(12)) on sc administered peptide tyrosine tyrosin...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Henry, Kelly E., Elfers, Clinton T., Burke, Rachael M., Chepurny, Oleg G., Holz, George G., Blevins, James E., Roth, Christian L., Doyle, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398759/
https://ncbi.nlm.nih.gov/pubmed/25658456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1825
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