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Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca(2+)-induced Ca(2+) Release and Exocytosis in Pancreatic β-Cells*
The second messenger cAMP exerts powerful stimulatory effects on Ca(2+) signaling and insulin secretion in pancreatic β-cells. Previous studies of β-cells focused on protein kinase A (PKA) as a downstream effector of cAMP action. However, it is now apparent that cAMP also exerts its effects by bindi...
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| Main Authors: | , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2002
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516291/ https://ncbi.nlm.nih.gov/pubmed/12496249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M211682200 |
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