Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca(2+)-induced Ca(2+) Release and Exocytosis in Pancreatic β-Cells*

The second messenger cAMP exerts powerful stimulatory effects on Ca(2+) signaling and insulin secretion in pancreatic β-cells. Previous studies of β-cells focused on protein kinase A (PKA) as a downstream effector of cAMP action. However, it is now apparent that cAMP also exerts its effects by bindi...

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Bibliographische Detailangaben
Hauptverfasser: Kang, Guoxin, Joseph, Jamie W., Chepurny, Oleg G., Monaco, Marie, Wheeler, Michael B., Bos, Johannes L., Schwede, Frank, Genieser, Hans-G., Holz, George G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516291/
https://ncbi.nlm.nih.gov/pubmed/12496249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M211682200
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