Enhanced Rap1 Activation and Insulin Secretagogue Properties of an Acetoxymethyl Ester of an Epac-selective Cyclic AMP Analog in Rat INS-1 Cells: STUDIES WITH 8-pCPT-2′-O-Me-cAMP-AM

To ascertain the identities of cyclic nucleotide-binding proteins that mediate the insulin secretagogue action of cAMP, the possible contributions of the exchange protein directly activated by cAMP (Epac) and protein kinase A (PKA) were evaluated in a pancreatic beta cell line (rat INS-1 cells). Ass...

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Hauptverfasser: Chepurny, Oleg G., Leech, Colin A., Kelley, Grant G., Dzhura, Igor, Dzhura, Elvira, Li, Xiangquan, Rindler, Michael J., Schwede, Frank, Genieser, Hans G., Holz, George G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667760/
https://ncbi.nlm.nih.gov/pubmed/19244230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900166200
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