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Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is triggered by metabolism of the sugar to increase ATP/ADP ratio that blocks the K(ATP) channel leading to membrane depolarization and insulin exocytosis. Other metabolic pathways believed to augment insulin secretion have yet to b...

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Autores principales: Lorenz, Matthew A., El Azzouny, Mahmoud A., Kennedy, Robert T., Burant, Charles F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624472/
https://ncbi.nlm.nih.gov/pubmed/23426361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414961
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