Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model

Metabolic deceleration in pancreatic β-cells is associated with inhibition of glucose-induced insulin secretion (GIIS), but only in the presence of intermediate/submaximal glucose concentrations. Here, we used acute metformin treatment as a tool to induce metabolic deceleration in INS1 (832/13) β-ce...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Lamontagne, Julien, Al-Mass, Anfal, Nolan, Christopher J., Corkey, Barbara E., Madiraju, S. R. Murthy, Joly, Erik, Prentki, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702682/
https://ncbi.nlm.nih.gov/pubmed/28972173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808105
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