Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic β-Cell at Submaximal Glucose Concentrations

Thiazolidinediones (TZDs) have beneficial effects on glucose homeostasis via enhancement of insulin sensitivity and preservation of β-cell function. How TZDs preserve β-cells is uncertain, but it might involve direct effects via both peroxisome proliferator-activated receptor-γ-dependent and -indepe...

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Main Authors: Lamontagne, Julien, Pepin, Émilie, Peyot, Marie-Line, Joly, Érik, Ruderman, Neil B., Poitout, Vincent, Madiraju, S. R. Murthy, Nolan, Christopher J., Prentki, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717855/
https://ncbi.nlm.nih.gov/pubmed/19406947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1557
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