Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early diabetes (HDR). C57BL/6N mice were fed for 8 weeks...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pepin, Émilie, Al-Mass, Anfal, Attané, Camille, Zhang, Kezhuo, Lamontagne, Julien, Lussier, Roxane, Madiraju, S. R. Murthy, Joly, Erik, Ruderman, Neil B., Sladek, Robert, Prentki, Marc, Peyot, Marie-Line
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820227/
https://ncbi.nlm.nih.gov/pubmed/27043434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153017
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