Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early diabetes (HDR). C57BL/6N mice were fed for 8 weeks...

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Publicado en:PLoS One
Autores principales: Pepin, Émilie, Al-Mass, Anfal, Attané, Camille, Zhang, Kezhuo, Lamontagne, Julien, Lussier, Roxane, Madiraju, S. R. Murthy, Joly, Erik, Ruderman, Neil B., Sladek, Robert, Prentki, Marc, Peyot, Marie-Line
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820227/
https://ncbi.nlm.nih.gov/pubmed/27043434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153017
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