Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies

Many metabolic studies employ tissue-specific gene knockout mice, which requires breeding of floxed gene mice, available mostly on C57BL/6N (NN) genetic background, with cre or Flp recombinase-expressing mice, available on C57BL/6J (JJ) background, resulting in the generation of mixed C57BL/6NJ (NJ)...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Attané, Camille, Peyot, Marie-Line, Lussier, Roxane, Zhang, Dongwei, Joly, Erik, Madiraju, S. R. Murthy, Prentki, Marc
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942110/
https://ncbi.nlm.nih.gov/pubmed/27403868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159165
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