Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

OBJECTIVE: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dys...

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Bibliografische gegevens
Gepubliceerd in:Mol Metab
Hoofdauteurs: Fergusson, Grace, Éthier, Mélanie, Guévremont, Mélanie, Chrétien, Chloé, Attané, Camille, Joly, Erik, Fioramonti, Xavier, Prentki, Marc, Poitout, Vincent, Alquier, Thierry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2014
Onderwerpen:
Brief Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264561/
https://ncbi.nlm.nih.gov/pubmed/25506550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.09.006
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