β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass

OBJECTIVE: C57Bl/6 mice develop obesity and mild hyperglycemia when fed a high-fat diet (HFD). Although diet-induced obesity (DIO) is a widely studied model of type 2 diabetes, little is known about β-cell failure in these mice. RESEARCH DESIGN AND METHODS: DIO mice were separated in two groups acco...

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Detalhes bibliográficos
Main Authors: Peyot, Marie-Line, Pepin, Emilie, Lamontagne, Julien, Latour, Martin G., Zarrouki, Bader, Lussier, Roxane, Pineda, Marco, Jetton, Thomas L., Madiraju, S.R. Murthy, Joly, Erik, Prentki, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927940/
https://ncbi.nlm.nih.gov/pubmed/20547980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1452
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