Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

The cellular and molecular mechanisms underpinning the compensatory increase in β-cell mass in response to insulin resistance are essentially unknown. We previously reported that a 72-h coinfusion of glucose and Intralipid (GLU+IL) induces insulin resistance and a marked increase in β-cell prolifera...

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Detalhes bibliográficos
Main Authors: Zarrouki, Bader, Benterki, Isma, Fontés, Ghislaine, Peyot, Marie-Line, Seda, Ondrej, Prentki, Marc, Poitout, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931394/
https://ncbi.nlm.nih.gov/pubmed/24194502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0425
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