Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early diabetes (HDR). C57BL/6N mice were fed for 8 weeks...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Pepin, Émilie, Al-Mass, Anfal, Attané, Camille, Zhang, Kezhuo, Lamontagne, Julien, Lussier, Roxane, Madiraju, S. R. Murthy, Joly, Erik, Ruderman, Neil B., Sladek, Robert, Prentki, Marc, Peyot, Marie-Line
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820227/
https://ncbi.nlm.nih.gov/pubmed/27043434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153017
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