Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early diabetes (HDR). C57BL/6N mice were fed for 8 weeks...

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Vydáno v:PLoS One
Hlavní autoři: Pepin, Émilie, Al-Mass, Anfal, Attané, Camille, Zhang, Kezhuo, Lamontagne, Julien, Lussier, Roxane, Madiraju, S. R. Murthy, Joly, Erik, Ruderman, Neil B., Sladek, Robert, Prentki, Marc, Peyot, Marie-Line
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820227/
https://ncbi.nlm.nih.gov/pubmed/27043434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153017
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