SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

OBJECTIVE: The reversible attachment of small ubiquitin-like modifier (SUMO) proteins controls target localization and function. We examined an acute role for the SUMOylation pathway in downstream events mediating insulin secretion. RESEARCH DESIGN AND METHODS: We studied islets and β-cells from mic...

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Autors principals: Dai, Xiao-Qing, Plummer, Greg, Casimir, Marina, Kang, Youhou, Hajmrle, Catherine, Gaisano, Herbert Y., Manning Fox, Jocelyn E., MacDonald, Patrick E.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046844/
https://ncbi.nlm.nih.gov/pubmed/21266332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0440
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