Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis

Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose homeos...

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Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: Zhu, Dan, Xie, Li, Kang, Youhou, Dolai, Subhankar, Bondo Hansen, Jakob, Qin, Tairan, Xie, Huanli, Liang, Tao, Rubin, Deborah C., Osborne, Lucy, Gaisano, Herbert Y.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2017
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860373/
https://ncbi.nlm.nih.gov/pubmed/28115395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0636
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