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K(v)2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3
The voltage-dependent K(+) (K(v)) channel K(v)2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, K(v)2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is independent of its ion-conducting pore function. Here, we...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5936832/ https://ncbi.nlm.nih.gov/pubmed/29549124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002703 |
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