K(v)2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3

The voltage-dependent K(+) (K(v)) channel K(v)2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, K(v)2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is independent of its ion-conducting pore function. Here, we...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Greitzer-Antes, Dafna, Xie, Li, Qin, Tairan, Xie, Huanli, Zhu, Dan, Dolai, Subhankar, Liang, Tao, Kang, Fei, Hardy, Alexandre B., He, Yan, Kang, Youhou, Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936832/
https://ncbi.nlm.nih.gov/pubmed/29549124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002703
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