An over-expression system for characterizing Ppt1 function in Drosophila

Por Korey, Christopher A, MacDonald, Marcy E
Publicado em 2003

Huntington's disease: the case for genetic modifiers

Por Gusella, James F, MacDonald, Marcy E
Publicado em 2009

Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation

Por Wang, Jin, Gines, Silvia, MacDonald, Marcy E, Gusella, James F
Publicado em 2005

Characterization of Mouse Striatal Precursor Cell Lines Expressing Functional Dopamine Receptors

Por Araki, Kiyomi Y., Fujimura, Satoshi, MacDonald, Marcy E., Bhide, Pradeep G.
Publicado em 2006

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

Por Faber, Peter W., Alter, Janet R., MacDonald, Marcy E., Hart, Anne C.
Publicado em 1999

Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening

Por Cheng, Chialin, Fass, Daniel M., Folz-Donahue, Kat, MacDonald, Marcy E., Haggarty, Stephen J.
Publicado no Curr Protoc Hum Genet (2017)

Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo

Por Woda, Juliana M, Calzonetti, Teresa, Hilditch-Maguire, Paige, Duyao, Mabel P, Conlon, Ronald A, MacDonald, Marcy E
Publicado em 2005

Genetic analysis of the GRIK2 modifier effect in Huntington's disease

Por Zeng, Wenqi, Gillis, Tammy, Hakky, Michael, Djoussé, Luc, Myers, Richard H, MacDonald, Marcy E, Gusella, James F
Publicado em 2006

Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

Por Myre, Michael A., Lumsden, Amanda L., Thompson, Morgan N., Wasco, Wilma, MacDonald, Marcy E., Gusella, James F.
Publicado em 2011

Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

Por Lee, Jong-Min, Ivanova, Elena V, Seong, Ihn Sik, Cashorali, Tanya, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E
Publicado em 2007

Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells

Por Cao, Yi, Staropoli, John F., Biswas, Sunita, Espinola, Janice A., MacDonald, Marcy E., Lee, Jong-Min, Cotman, Susan L.
Publicado em 2011

Palmitoyl-Protein Thioesterase 1 Deficiency in Drosophila melanogaster Causes Accumulation of Abnormal Storage Material and Reduced Life Span

Por Hickey, Anthony J., Chotkowski, Heather L., Singh, Navjot, Ault, Jeffrey G., Korey, Christopher A., MacDonald, Marcy E., Glaser, Robert L.
Publicado em 2006

Biotin-Responsive Basal Ganglia Disease Maps to 2q36.3 and Is Due to Mutations in SLC19A3

Por Zeng, Wen-Qi , Al-Yamani, Eiman , Acierno, Jr., James S. , Slaugenhaupt, Susan , Gillis, Tammy , MacDonald, Marcy E. , Ozand, Pinar T. , Gusella, James F. 
Publicado em 2005

Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease

Por Carnemolla, Alisia, Fossale, Elisa, Agostoni, Elena, Michelazzi, Silvia, Calligaris, Raffaella, De Maso, Luca, Del Sal, Giannino, MacDonald, Marcy E., Persichetti, Francesca
Publicado em 2009

Huntingtin inhibits caspase-3 activation

Por Zhang, Yu, Leavitt, Blair R, van Raamsdonk, Jeremy M, Dragatsis, Ioannis, Goldowitz, Dan, MacDonald, Marcy E, Hayden, Michael R, Friedlander, Robert M
Publicado em 2006

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9

Por Shin, Jun Wan, Kim, Kyung-Hee, Chao, Michael J., Atwal, Ranjit S., Gillis, Tammy, MacDonald, Marcy E., Gusella, James F., Lee, Jong-Min
Publicado no Hum Mol Genet (2016)

Estimating the Probability of de novo HD cases from Transmissions of Expanded Penetrant CAG Alleles in the Huntington Disease Gene from Male Carriers of High Normal Alleles (27–35...

Por Hendricks, Audrey E., Latourelle, Jeanne C., Lunetta, Kathryn L., Cupples, L. Adrienne, Wheeler, Vanessa, MacDonald, Marcy E., Gusella, James F., Myers, Richard H.
Publicado em 2009

Hdh(Q111) Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation

Por Carroll, Jeffrey B., Deik, Amy, Fossale, Elisa, Weston, Rory M., Guide, Jolene R., Arjomand, Jamshid, Kwak, Seung, Clish, Clary B., MacDonald, Marcy E.
Publicado no PLoS One (2015)

Meclizine is neuroprotective in models of Huntington's disease

Por Gohil, Vishal M., Offner, Nicolas, Walker, James A., Sheth, Sunil A., Fossale, Elisa, Gusella, James F., MacDonald, Marcy E., Neri, Christian, Mootha, Vamsi K.
Publicado em 2011

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

Por Fossale, Elisa, Seong, Ihn Sik, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Publicado em 2011