Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver

Por Lee, Jong-Min, Pinto, Ricardo Mouro, Gillis, Tammy, St. Claire, Jason C., Wheeler, Vanessa C.
Publicado em 2011

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

Por Goula, Agathi-Vassiliki, Berquist, Brian R., Wilson, David M., Wheeler, Vanessa C., Trottier, Yvon, Merienne, Karine
Publicado em 2009

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

Por Swami, Meera, Hendricks, Audrey E., Gillis, Tammy, Massood, Tiffany, Mysore, Jayalakshmi, Myers, Richard H., Wheeler, Vanessa C.
Publicado em 2009

Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

Por Mochel, Fanny, Durant, Brandon, Meng, Xingli, O'Callaghan, James, Yu, Hua, Brouillet, Emmanuel, Wheeler, Vanessa C., Humbert, Sandrine, Schiffmann, Raphael, Durr, Alexandra
Publicado em 2012

Rolling Circle Amplification : A New Approach to Increase Sensitivity for Immunohistochemistry and Flow Cytometry

Por Gusev, Yuriy, Sparkowski, Jason, Raghunathan, Arumugham, Ferguson, Harley, Montano, Jane, Bogdan, Nancy, Schweitzer, Barry, Wiltshire, Steven, Kingsmore, Stephen F., Maltzman, Warren, Wheeler, Vanessa
Publicado em 2001

Estimating the Probability of de novo HD cases from Transmissions of Expanded Penetrant CAG Alleles in the Huntington Disease Gene from Male Carriers of High Normal Alleles (27–35...

Por Hendricks, Audrey E., Latourelle, Jeanne C., Lunetta, Kathryn L., Cupples, L. Adrienne, Wheeler, Vanessa, MacDonald, Marcy E., Gusella, James F., Myers, Richard H.
Publicado em 2009

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

Por Fossale, Elisa, Seong, Ihn Sik, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Publicado em 2011

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

Por Neto, João Luís, Lee, Jong-Min, Afridi, Ali, Gillis, Tammy, Guide, Jolene R., Dempsey, Stephani, Lager, Brenda, Alonso, Isabel, Wheeler, Vanessa C., Pinto, Ricardo Mouro
Publicado no Genetics (2017)

Chromosome substitution strain assessment of a Huntington’s disease modifier locus

Por Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.
Publicado no Mamm Genome (2015)

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

Por Dragileva, Ella, Hendricks, Audrey, Teed, Allison, Gillis, Tammy, Lopez, Edith T, Friedberg, Errol C, Kucherlapati, Raju, Edelmann, Winfried, Lunetta, Kathryn L, MacDonald, Marcy E, Wheeler, Vanessa C
Publicado em 2008

HD CAGnome: A Search Tool for Huntingtin CAG Repeat Length-Correlated Genes

Por Galkina, Ekaterina I., Shin, Aram, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Seong, Ihn Sik, Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Publicado em 2014

Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport

Por Gasset-Rosa, Fatima, Chillon-Marinas, Carlos, Goginashvili, Alexander, Atwal, Ranjit Singh, Artates, Jonathan W., Tabet, Ricardos, Wheeler, Vanessa C., Bang, Anne G., Cleveland, Don W., Lagier-Tourenne, Clotilde
Publicado no Neuron (2017)

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

Por Kovalenko, Marina, Dragileva, Ella, St. Claire, Jason, Gillis, Tammy, Guide, Jolene R., New, Jaclyn, Dong, Hualing, Kucherlapati, Raju, Kucherlapati, Melanie H., Ehrlich, Michelle E., Lee, Jong-Min, Wheeler, Vanessa C.
Publicado em 2012

The Genetic Modifiers of Motor Onset Age (GeM MOA) website: genome-wide association analysis for genetic modifiers of Huntington's disease

Por Correia, Kevin, Harold, Denise, Kim, Kyung-Hee, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H., Kwak, Seung, Wheeler, Vanessa C., MacDonald, Marcy E., Gusella, James F., Lee, Jong-Min
Publicado no J Huntingtons Dis (2015)

Transcriptional Consequences of 16p11.2 Deletion and Duplication in Mouse Cortex and Multiplex Autism Families

Por Blumenthal, Ian, Ragavendran, Ashok, Erdin, Serkan, Klei, Lambertus, Sugathan, Aarathi, Guide, Jolene R., Manavalan, Poornima, Zhou, Julian Q., Wheeler, Vanessa C., Levin, Joshua Z., Ernst, Carl, Roeder, Kathryn, Devlin, Bernie, Gusella, James F., Talkowski, Michael E.
Publicado em 2014

A novel approach to investigate tissue-specific trinucleotide repeat instability

Por Lee, Jong-Min, Zhang, Jie, Su, Andrew I, Walker, John R, Wiltshire, Tim, Kang, Kihwa, Dragileva, Ella, Gillis, Tammy, Lopez, Edith T, Boily, Marie-Josee, Cyr, Michel, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E, Wheeler, Vanessa C
Publicado em 2010

Haplotype-based stratification of Huntington's disease

Por Chao, Michael J, Gillis, Tammy, Atwal, Ranjit S, Mysore, Jayalakshmi Srinidhi, Arjomand, Jamshid, Harold, Denise, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min
Publicado no Eur J Hum Genet (2017)

Huntingtin facilitates polycomb repressive complex 2

Por Seong, Ihn Sik, Woda, Juliana M., Song, Ji-Joon, Lloret, Alejandro, Abeyrathne, Priyanka D., Woo, Caroline J., Gregory, Gillian, Lee, Jong-Min, Wheeler, Vanessa C., Walz, Thomas, Kingston, Robert E., Gusella, James F., Conlon, Ronald A., MacDonald, Marcy E.
Publicado em 2010

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

Por Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, St. Claire, Jason, Panigrahi, Gagan B., Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R., Cohen, Paula E., Li, Guo-Min, Pearson, Christopher E., Daly, Mark J., Wheeler, Vanessa C.
Publicado em 2013

Systematic behavioral evaluation of Huntington’s disease transgenic and knock-in mouse models

Por Menalled, Liliana, El-Khodor, Bassem F., Patry, Monica, Suarez-Farinas, Mayte, Orenstein, Samantha, Zahasky, Benjamin, Leahy, Christina, Wheeler, Vanessa, Yang, X. William, MacDonald, Marcy, Morton, Jennifer A., Bates, Gill, Leeds, Janet, Park, Larry, Howland, David, Signer, Ethan, Tobin, Allan, Brunner, Daniela
Publicado em 2009