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Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative
Huntington's disease (HD) involves marked early neurodegeneration in the striatum, whereas the cerebellum is relatively spared despite the ubiquitous expression of full-length mutant huntingtin, implying that inherent tissue-specific differences determine susceptibility to the HD CAG mutation....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3188996/ https://ncbi.nlm.nih.gov/pubmed/21840924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr355 |
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