Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

Huntington's disease (HD) involves marked early neurodegeneration in the striatum, whereas the cerebellum is relatively spared despite the ubiquitous expression of full-length mutant huntingtin, implying that inherent tissue-specific differences determine susceptibility to the HD CAG mutation....

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Bibliographische Detailangaben
Hauptverfasser: Fossale, Elisa, Seong, Ihn Sik, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188996/
https://ncbi.nlm.nih.gov/pubmed/21840924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr355
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