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Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

Huntington's disease (HD) involves marked early neurodegeneration in the striatum, whereas the cerebellum is relatively spared despite the ubiquitous expression of full-length mutant huntingtin, implying that inherent tissue-specific differences determine susceptibility to the HD CAG mutation....

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書誌詳細
主要な著者: Fossale, Elisa, Seong, Ihn Sik, Coser, Kathryn R., Shioda, Toshi, Kohane, Isaac S., Wheeler, Vanessa C., Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188996/
https://ncbi.nlm.nih.gov/pubmed/21840924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr355
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