HD CAG-correlated gene expression changes support a simple dominant gain of function

Huntington's disease is initiated by the expression of a CAG repeat-encoded polyglutamine region in full-length huntingtin, with dominant effects that vary continuously with CAG size. The mechanism could involve a simple gain of function or a more complex gain of function coupled to a loss of f...

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Main Authors: Jacobsen, Jessie C., Gregory, Gillian C., Woda, Juliana M., Thompson, Morgan N., Coser, Kathryn R., Murthy, Vidya, Kohane, Isaac S., Gusella, James F., Seong, Ihn Sik, MacDonald, Marcy E., Shioda, Toshi, Lee, Jong-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118763/
https://ncbi.nlm.nih.gov/pubmed/21536587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr195
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